› 5j0f

X-ray diffraction
1.25Å resolution

Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P4/5

Released:
DOI: 10.2210/pdb5j0f/pdb
PDB entry 5j0f coloured by chain, front view.
PDB entry 5j0f coloured by chain, side view.
PDB entry 5j0f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Tricking a Protein To Swap Strands.
Wang H, Lang L, Logan DT, Danielsson J, Oliveberg M
J Am Chem Soc 138 15571-15579 (2016)
PMID: 27783493

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132490 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Cu-Zn] Chains: A, B
Molecule details ›
Chains: A, B
Length: 114 amino acids
Theoretical weight: 11.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P00441 (Residues: 2-49; Coverage: 31%)
Gene name: SOD1

Ligands and Environments

1 bound ligand:
Ligand GOL 5 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P65
Unit cell:
a: 71.72Å b: 71.72Å c: 69.51Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.131 0.129 0.17
Expression system: Escherichia coli K-12

Quick links

Citations

3 citation in other articles

TFE-induced local unfolding and fibrillation of SOD1: bridging the experiment and simulation studies.
Kumar et al. (2018)
2 more

1 mention without citation

Structural Properties and Interaction Partners of Familial ALS-Associated SOD1 Mutants.
Huai et al. (2019)