Function and Biology Details
Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Inhibitor of growth protein, N-terminal histone-binding
- Chromatin modification-related protein Eaf6
- Histone acetyltransferase domain, MYST-type
- ING family
- Enhancer of polycomb-like, N-terminal
- Enhancer of polycomb protein
- Winged helix-like DNA-binding domain superfamily
- MYST, zinc finger domain
1 more domain
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-153731 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Histone acetyltransferase ESA1
Molecule details ›
Chains: A, E, I
Length: 305 amino acids
Theoretical weight: 36.56 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 305 amino acids
Theoretical weight: 36.56 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
- Canonical:
Q08649 (Residues: 141-445; Coverage: 69%)
Sequence domains:
Chromatin modification-related protein EAF6
Molecule details ›
Chains: B, F, J
Length: 113 amino acids
Theoretical weight: 12.92 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
Sequence domains: Histone acetyltransferase subunit NuA4
Length: 113 amino acids
Theoretical weight: 12.92 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
- Canonical: P47128 (Residues: 1-113; Coverage: 100%)
Sequence domains: Histone acetyltransferase subunit NuA4
Enhancer of polycomb-like protein 1
Molecule details ›
Chains: C, G, N
Length: 351 amino acids
Theoretical weight: 41.84 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
Sequence domains: Enhancer of polycomb-like
Length: 351 amino acids
Theoretical weight: 41.84 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
- Canonical: P43572 (Residues: 50-400; Coverage: 42%)
Sequence domains: Enhancer of polycomb-like
Chromatin modification-related protein YNG2
Molecule details ›
Chains: D, H, K
Length: 120 amino acids
Theoretical weight: 13.83 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
Sequence domains: Inhibitor of growth proteins N-terminal histone-binding
Length: 120 amino acids
Theoretical weight: 13.83 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
- Canonical: P38806 (Residues: 1-120; Coverage: 43%)
Sequence domains: Inhibitor of growth proteins N-terminal histone-binding
Histone H2A.Z
