› 5jl9

X-ray diffraction
3.1Å resolution

HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1): ANDROSTENEDIONE COMPLEX #4

Released:
DOI: 10.2210/pdb5jl9/pdb
PDB entry 5jl9 coloured by chain, front view.
PDB entry 5jl9 coloured by chain, side view.
PDB entry 5jl9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Testosterone complex and non-steroidal ligands of human aromatase.
Ghosh D, Egbuta C, Lo J
J Steroid Biochem Mol Biol 181 11-19 (2018)
PMID: 29476820

Function and Biology Details

Reaction catalysed: 
(1a) testosterone + [reduced NADPH--hemoprotein reductase] + O(2) = 19-hydroxytestosterone + H(2)O + [oxidized NADPH--hemoprotein reductase]
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145862 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aromatase Chain: A
Molecule details ›
Chain: A
Length: 503 amino acids
Theoretical weight: 57.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P11511 (Residues: 1-503; Coverage: 100%)
Gene names: ARO1, CYAR, CYP19, CYP19A1
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments


Cofactor: Ligand HEM 1 x HEM
1 bound ligand:
Ligand ASD 1 x ASD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3221
Unit cell:
a: 140.016Å b: 140.016Å c: 119.379Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.189 0.211

Quick links

Citations

4 review citations

Human cytochrome P450 enzymes 5-51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition - toxic effects and benefits.
Rendic et al. (2018)
3 more

3 mentions without citation

Testosterone complex and non-steroidal ligands of human aromatase.
Ghosh et al. (2018)
2 more