› 5jo3

X-ray diffraction
1.49Å resolution

PDE5A for NaV1.7

Released:
DOI: 10.2210/pdb5jo3/pdb
PDB entry 5jo3 coloured by chain, front view.
PDB entry 5jo3 coloured by chain, side view.
PDB entry 5jo3 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Storer I, Chrencik J

Function and Biology Details

Reaction catalysed: 
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131208 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cGMP-specific 3',5'-cyclic phosphodiesterase Chain: B
Molecule details ›
Chain: B
Length: 326 amino acids
Theoretical weight: 37.61 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O76074 (Residues: 534-676, 677-858; Coverage: 37%)
Gene names: PDE5, PDE5A
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase
Structure domains: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand 6LK 1 x 6LK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2
Unit cell:
a: 55.84Å b: 76.1Å c: 80.92Å
α: 90° β: 102.56° γ: 90°
R-values:
R R work R free
0.181 0.18 0.201
Expression system: Spodoptera frugiperda

Quick links