› 5jog

X-ray diffraction
2.46Å resolution

CRYSTAL STRUCTURE OF CSN5(2-257) IN COMPLEX WITH CNS5i-3

Released:
DOI: 10.2210/pdb5jog/pdb
PDB entry 5jog coloured by chain, front view.
PDB entry 5jog coloured by chain, side view.
PDB entry 5jog coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Targeted inhibition of the COP9 signalosome for treatment of cancer.
Schlierf A, Altmann E, Quancard J, Jefferson AB, Assenberg R, Renatus M, Jones M, Hassiepen U, Schaefer M, Kiffe M, Weiss A, Wiesmann C, Sedrani R, Eder J, Martoglio B
Nat Commun 7 13166 (2016)
PMID: 27774986

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
COP9 signalosome complex subunit 5 Chain: A
Molecule details ›
Chain: A
Length: 257 amino acids
Theoretical weight: 28.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92905 (Residues: 2-257; Coverage: 77%)
Gene names: COPS5, CSN5, JAB1
Sequence domains: JAB1/Mov34/MPN/PAD-1 ubiquitin protease

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand 6LT 1 x 6LT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: I4
Unit cell:
a: 101.363Å b: 101.363Å c: 68.602Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.243
Expression system: Escherichia coli

Quick links

Citations

21 review citations

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway.
Baird et al. (2020)
20 more

9 mentions without citation

Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease.
Pan et al. (2022)
8 more