› 5jpw

Solution NMR

Molecular basis for protein recognition specificity of the DYNLT1/Tctex1 canonical binding groove. Characterization of the interaction with activin receptor IIB

Released:
DOI: 10.2210/pdb5jpw/pdb
PDB entry 5jpw coloured by chain, ensemble of 20 models, front view.
PDB entry 5jpw coloured by chain, ensemble of 20 models, side view.
PDB entry 5jpw coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Molecular Basis for the Protein Recognition Specificity of the Dynein Light Chain DYNLT1/Tctex1: CHARACTERIZATION OF THE INTERACTION WITH ACTIVIN RECEPTOR IIB.
Merino-Gracia J, Zamora-Carreras H, Bruix M, Rodríguez-Crespo I
J Biol Chem 291 20962-20975 (2016)
PMID: 27502274

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159029 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytoplasmic dynein 1 intermediate chain 2; Dynein light chain Tctex-type 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 143 amino acids
Theoretical weight: 15.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63172 (Residues: 1-113; Coverage: 100%)
  • Canonical: Q13409 (Residues: 134-154; Coverage: 3%)
Gene names: DNCI2, DNCIC2, DYNC1I2, DYNLT1, TCTEL1, TCTEX-1, TCTEX1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 72%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Structural atlas of dynein motors at atomic resolution.
Toda et al. (2018)
6 other articles

2 mentions without citation

Molecular Basis for the Protein Recognition Specificity of the Dynein Light Chain DYNLT1/Tctex1: CHARACTERIZATION OF THE INTERACTION WITH ACTIVIN RECEPTOR IIB.
Merino-Gracia et al. (2016)
1 more