5jqt

X-ray diffraction
1.36Å resolution

Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH 7.4

Released:

Function and Biology Details

Reactions catalysed:
H(2)CO(3) = CO(2) + H(2)O
Urea = cyanamide + H(2)O
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133681 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 2 Chain: A
Molecule details ›
Chain: A
Length: 262 amino acids
Theoretical weight: 29.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 42.234Å b: 41.104Å c: 71.831Å
α: 90° β: 103.92° γ: 90°
R-values:
R R work R free
0.123 0.121 0.165
Expression system: Escherichia coli BL21(DE3)