› 5jsb

X-ray diffraction
2.74Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-165873 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1 Chains: A, C, E, G, I, K
Molecule details ›
Chains: A, C, E, G, I, K
Length: 179 amino acids
Theoretical weight: 20.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07820 (Residues: 172-350; Coverage: 51%)
Gene names: BCL2L3, MCL1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
Mcl-1 inhibitor Chains: B, D, F, H, J, L
Molecule details ›
Chains: B, D, F, H, J, L
Length: 116 amino acids
Theoretical weight: 13.63 KDa
Source organism: synthetic construct
Expression system: Escherichia coli BL21(DE3)
Structure domains: Ribosome-recycling factor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 61.917Å b: 92.246Å c: 162.005Å
α: 90° β: 92.39° γ: 90°
R-values:
R R work R free
0.193 0.191 0.23
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy.
Ramesh et al. (2020)
5 more

5 mentions without citation

Progress in targeting the BCL-2 family of proteins.
Garner et al. (2017)
4 more