› 5jsn

X-ray diffraction
2.1Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145306 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Apoptosis regulator Bcl-2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 215 amino acids
Theoretical weight: 23.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10415 (Residues: 1-207; Coverage: 87%)
Gene name: BCL2
Sequence domains:
Bcl2 inhibitor Chains: B, D
Molecule details ›
Chains: B, D
Length: 118 amino acids
Theoretical weight: 13.85 KDa
Source organism: unidentified
Expression system: Escherichia coli BL21(DE3)
Structure domains: Ribosome-recycling factor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-D
Spacegroup: P41
Unit cell:
a: 65.005Å b: 65.005Å c: 134.314Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.159 0.205
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy.
Ramesh et al. (2020)
7 more

16 mentions without citation

Bulbus Fritillariae Cirrhosae as a Respiratory Medicine: Is There a Potential Drug in the Treatment of COVID-19?
Quan et al. (2021)
15 more