Function and Biology Details
Reaction catalysed:
Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-|-Xaa
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero octadecamer (preferred)
PDBe Complex ID:
PDB-CPX-127067 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Apoptotic protease-activating factor 1
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 1248 amino acids
Theoretical weight: 142.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 1248 amino acids
Theoretical weight: 142.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
O14727 (Residues: 1-1248; Coverage: 100%)
Sequence domains:
Cytochrome c
Molecule details ›
Chains: H, I, J, K, L, M, N
Length: 104 amino acids
Theoretical weight: 11.6 KDa
Source organism: Bos taurus
UniProt:
Sequence domains: Cytochrome c
Length: 104 amino acids
Theoretical weight: 11.6 KDa
Source organism: Bos taurus
UniProt:
- Canonical: P62894 (Residues: 2-105; Coverage: 99%)
Sequence domains: Cytochrome c
Caspase-9 subunit p35
Molecule details ›
Chains: O, P, Q, R
Length: 95 amino acids
Theoretical weight: 11.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
Sequence domains: Caspase recruitment domain
Length: 95 amino acids
Theoretical weight: 11.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
- Canonical: P55211 (Residues: 1-95; Coverage: 23%)
Sequence domains: Caspase recruitment domain
