5jxi

X-ray diffraction
2Å resolution

Structure of the unliganded form of the proprotein convertase furin in presence of EDTA.

Released:

Function and Biology Details

Reaction catalysed:
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140840 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Furin Chain: A
Molecule details ›
Chain: A
Length: 482 amino acids
Theoretical weight: 52.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P09958 (Residues: 108-574; Coverage: 61%)
Gene names: FUR, FURIN, PACE, PCSK3
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P6522
Unit cell:
a: 132.448Å b: 132.448Å c: 155.673Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.159 0.158 0.185
Expression system: Homo sapiens