› 5jy3

X-ray diffraction
2.4Å resolution

CRYSTAL STRUCTURE OF LXRbeta (NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 2) COMPLEXED WITH BMS-852927

Released:
DOI: 10.2210/pdb5jy3/pdb
PDB entry 5jy3 coloured by chain, front view.
PDB entry 5jy3 coloured by chain, side view.
PDB entry 5jy3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of Highly Potent Liver X Receptor β Agonists.
Kick EK, Busch BB, Martin R, Stevens WC, Bollu V, Xie Y, Boren BC, Nyman MC, Nanao MH, Nguyen L, Plonowski A, Schulman IG, Yan G, Zhang H, Hou X, Valente MN, Narayanan R, Behnia K, Rodrigues AD, Brock B, Smalley J, Cantor GH, Lupisella J, Sleph P, Grimm D, Ostrowski J, Wexler RR, Kirchgessner T, Mohan R
ACS Med Chem Lett 7 1207-1212 (2016)
PMID: 27994765

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157162 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxysterols receptor LXR-beta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 264 amino acids
Theoretical weight: 30.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55055 (Residues: 213-460; Coverage: 54%)
Gene names: LXRB, NER, NR1H2, UNR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand 6OX 4 x 6OX
Ligand BU1 2 x BU1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: C2
Unit cell:
a: 183.66Å b: 120.35Å c: 55.72Å
α: 90° β: 107.49° γ: 90°
R-values:
R R work R free
0.229 0.225 0.268
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Liver X receptors link lipid metabolism and inflammation.
Schulman IG. (2017)
3 more

3 mentions without citation

Discovery of Highly Potent Liver X Receptor β Agonists.
Kick et al. (2016)
2 more