Function and Biology Details
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130890 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ubiquitin carboxyl-terminal hydrolase 12
Molecule details ›
Chains: A, C, E, G
Length: 331 amino acids
Theoretical weight: 38.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
Sequence domains: Ubiquitin carboxyl-terminal hydrolase
Length: 331 amino acids
Theoretical weight: 38.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
- Canonical:
O75317 (Residues: 40-370; Coverage: 90%)
Sequence domains: Ubiquitin carboxyl-terminal hydrolase
WD repeat-containing protein 48
Molecule details ›
Chains: B, D, F, H
Length: 677 amino acids
Theoretical weight: 76.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
Sequence domains:
Length: 677 amino acids
Theoretical weight: 76.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
- Canonical: Q8TAF3 (Residues: 1-677; Coverage: 100%)
Sequence domains:
