› 5k6j

X-ray diffraction
1.86Å resolution

Human Phospodiesterase 4B in complex with pyridyloxy-benzoxaborole based inhibitor

Released:
DOI: 10.2210/pdb5k6j/pdb
PDB entry 5k6j coloured by chain, front view.
PDB entry 5k6j coloured by chain, side view.
PDB entry 5k6j coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Rock FL, Zhou Y, Sullivan D

Function and Biology Details

Reaction catalysed: 
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170460 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3',5'-cyclic-AMP phosphodiesterase 4B Chain: A
Molecule details ›
Chain: A
Length: 323 amino acids
Theoretical weight: 37.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07343 (Residues: 334-656; Coverage: 44%)
Gene names: DPDE4, PDE4B
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase
Structure domains: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Ligands and Environments

4 bound ligands:
Ligand ZN 1 x ZN
Ligand MG 1 x MG
Ligand 6QQ 1 x 6QQ
Ligand EDO 17 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P43212
Unit cell:
a: 53.839Å b: 53.839Å c: 229.85Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.235
Expression system: Escherichia coli

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