› 5kiz

Solution NMR

Solution Structure of a repacked version of HIF-2 alpha PAS-B

Released:
DOI: 10.2210/pdb5kiz/pdb
PDB entry 5kiz coloured by chain, ensemble of 20 models, front view.
PDB entry 5kiz coloured by chain, ensemble of 20 models, side view.
PDB entry 5kiz coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Computational Repacking of HIF-2α Cavity Replaces Water-Based Stabilized Core.
Corrêa F, Key J, Kuhlman B, Gardner KH
Structure 24 1918-1927 (2016)
PMID: 27667693

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189272 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endothelial PAS domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 13.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99814 (Residues: 239-349; Coverage: 13%)
Gene names: BHLHE73, EPAS1, HIF2A, MOP2, PASD2
Sequence domains: PAS domain
Structure domains: PAS domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 92%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

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Citations

1 review citation

Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets.
Zhao et al. (2023)
2 other articles