Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- NUDIX hydrolase domain
- mRNA decapping protein 2, Box A domain
- mRNA decapping protein 2, Box A domain superfamily
- mRNA-decapping enzyme subunit 1
- Proline-rich nuclear receptor coactivator 1/2
- NUDIX hydrolase, conserved site
- mRNA decapping enzyme 2 , NUDIX hydrolase domain
- NUDIX hydrolase-like domain superfamily
1 more domain
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-126918 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
mRNA-decapping enzyme subunit 1
Molecule details ›
Chains: A, D
Length: 130 amino acids
Theoretical weight: 15.34 KDa
Source organism: Schizosaccharomyces pombe 972h-
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Dcp1-like decapping family
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Length: 130 amino acids
Theoretical weight: 15.34 KDa
Source organism: Schizosaccharomyces pombe 972h-
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q9P805 (Residues: 1-127; Coverage: 100%)
Sequence domains: Dcp1-like decapping family
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Proline-rich nuclear receptor coactivator 2
Molecule details ›
Chains: C, F
Length: 31 amino acids
Theoretical weight: 3.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Proline-rich nuclear receptor coactivator motif
Length: 31 amino acids
Theoretical weight: 3.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q9NPJ4 (Residues: 91-121; Coverage: 22%)
Sequence domains: Proline-rich nuclear receptor coactivator motif
mRNA decapping complex subunit 2
Molecule details ›
Chains: B, E
Length: 249 amino acids
Theoretical weight: 28.95 KDa
Source organism: Schizosaccharomyces pombe 972h-
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 249 amino acids
Theoretical weight: 28.95 KDa
Source organism: Schizosaccharomyces pombe 972h-
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: O13828 (Residues: 1-244; Coverage: 33%)
Sequence domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ALS BEAMLINE 8.3.1
Spacegroup:
P21
Expression system: Escherichia coli BL21(DE3)
