› 5kq8

X-ray diffraction
2Å resolution

PANK3-AMPPN complex

Released:
DOI: 10.2210/pdb5kq8/pdb
PDB entry 5kq8 coloured by chain, front view.
PDB entry 5kq8 coloured by chain, side view.
PDB entry 5kq8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Allosteric Regulation of Mammalian Pantothenate Kinase.
Subramanian C, Yun MK, Yao J, Sharma LK, Lee RE, White SW, Jackowski S, Rock CO
J Biol Chem 291 22302-22314 (2016)
PMID: 27555321

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190695 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pantothenate kinase 3 Chain: A
Molecule details ›
Chain: A
Length: 380 amino acids
Theoretical weight: 42.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H999 (Residues: 12-370; Coverage: 97%)
Gene name: PANK3
Sequence domains: Fumble
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand AN2 1 x AN2
Ligand MG 1 x MG
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3121
Unit cell:
a: 98.477Å b: 98.477Å c: 68.495Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.181 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Patient-Derived Cellular Models for Polytarget Precision Medicine in Pantothenate Kinase-Associated Neurodegeneration.
Álvarez-Córdoba et al. (2023)
1 more

3 mentions without citation

Allosteric Regulation of Mammalian Pantothenate Kinase.
Subramanian et al. (2016)
2 more