› 5ku9

X-ray diffraction
2.2Å resolution

Function and Biology Details

Reaction catalysed: 
(Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161275 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Induced myeloid leukemia cell differentiation protein Mcl-1; Induced myeloid leukemia cell differentiation protein Mcl-1 homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 162 amino acids
Theoretical weight: 18.23 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P97287 (Residues: 148-221; Coverage: 22%)
  • Canonical: Q07820 (Residues: 241-327; Coverage: 25%)
Gene names: BCL2L3, MCL1, Mcl1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like

Ligands and Environments

2 bound ligands:
Ligand NA 1 x NA
Ligand 6XJ 2 x 6XJ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 84.381Å b: 60.647Å c: 69.087Å
α: 90° β: 121.15° γ: 90°
R-values:
R R work R free
0.19 0.187 0.241
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy.
Hengel et al. (2017)
7 more

2 mentions without citation

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.
Johannes et al. (2017)
1 more