› 5kvt

X-ray diffraction
2.45Å resolution

THE STRUCTURE OF TRKA KINASE DOMAIN BOUND TO THE INHIBITOR ENTRECTINIB

Released:
DOI: 10.2210/pdb5kvt/pdb
PDB entry 5kvt coloured by chain, front view.
PDB entry 5kvt coloured by chain, side view.
PDB entry 5kvt coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Jin L, Yan S, Wei G, Li G, Harris J, Vernier J-M

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
High affinity nerve growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 293 amino acids
Theoretical weight: 33.51 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04629 (Residues: 501-787; Coverage: 38%)
Gene names: MTC, NTRK1, TRK, TRKA
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand YMX 1 x YMX
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P64
Unit cell:
a: 75.9Å b: 75.9Å c: 111.74Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.192 0.239
Expression system: Spodoptera frugiperda

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