5kyu

X-ray diffraction
3.51Å resolution

crystal structure of Sec23 and TANGO1 peptide2 complex

Released:
Source organism: Homo sapiens
Primary publication:
TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats.
Proc Natl Acad Sci U S A 113 10061-6 (2016)
PMID: 27551091

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-131779 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Protein transport protein Sec23A Chain: A
Molecule details ›
Chain: A
Length: 765 amino acids
Theoretical weight: 86.25 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: Q15436 (Residues: 1-765; Coverage: 100%)
Gene name: SEC23A
Sequence domains:
Structure domains:
Protein transport protein Sec24D Chain: B
Molecule details ›
Chain: B
Length: 767 amino acids
Theoretical weight: 86.39 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: O94855 (Residues: 266-1032; Coverage: 74%)
Gene names: KIAA0755, SEC24D
Sequence domains:
Structure domains:
Transport and Golgi organization protein 1 homolog Chain: C
Molecule details ›
Chain: C
Length: 8 amino acids
Theoretical weight: 831 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q5JRA6 (Residues: 1796-1803; Coverage: 0%)
Gene names: KIAA0268, MIA3, TANGO, UNQ6077/PRO20088

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 103.428Å b: 140.926Å c: 150.603Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.217 0.267
Expression systems:
  • Insect cell expression vector pTIE1
  • Not provided