› 5kyy

X-ray diffraction
3.4Å resolution

Crystal structure of Sec23 and TANGO1 peptide4 complex

Released:
DOI: 10.2210/pdb5kyy/pdb
PDB entry 5kyy coloured by chain, front view.
PDB entry 5kyy coloured by chain, side view.
PDB entry 5kyy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats.
Ma W, Goldberg J
Proc Natl Acad Sci U S A 113 10061-6 (2016)
PMID: 27551091

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131778 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein transport protein Sec23A Chain: A
Molecule details ›
Chain: A
Length: 765 amino acids
Theoretical weight: 86.25 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: Q15436 (Residues: 1-765; Coverage: 100%)
Gene name: SEC23A
Sequence domains:
Structure domains:
Protein transport protein Sec24D Chain: B
Molecule details ›
Chain: B
Length: 770 amino acids
Theoretical weight: 86.65 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: O94855 (Residues: 266-1032; Coverage: 74%)
Gene names: KIAA0755, SEC24D
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 101.386Å b: 139.056Å c: 149.444Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.177 0.252
Expression system: Insect cell expression vector pTIE1

Quick links

Citations

16 review citations

Protein sorting at the ER-Golgi interface.
Gomez-Navarro et al. (2016)
15 more

1 mention without citation

TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats.
Ma et al. (2016)