› 5kzn

X-ray diffraction
2.8Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171998 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 570 amino acids
Theoretical weight: 63.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14416 (Residues: 1-564; Coverage: 64%)
Gene names: GPRC1B, GRM2, MGLUR2
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P6522
Unit cell:
a: 129.85Å b: 129.85Å c: 252.483Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.22 0.249
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

mGlu2/3 Receptor Antagonists as Novel Antidepressants.
Chaki S. (2017)
4 more

4 mentions without citation

Structural insights into the activation of metabotropic glutamate receptors.
Koehl et al. (2019)
3 more