› 5kzo

Solution NMR

Notch1 transmembrane and associated juxtamembrane segment

Released:
DOI: 10.2210/pdb5kzo/pdb
PDB entry 5kzo coloured by chain, ensemble of 10 models, front view.
PDB entry 5kzo coloured by chain, ensemble of 10 models, side view.
PDB entry 5kzo coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains.
Deatherage CL, Lu Z, Kroncke BM, Ma S, Smith JA, Voehler MW, McFeeters RL, Sanders CR
Sci Adv 3 e1602794 (2017)
PMID: 28439555

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155479 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Notch 1 intracellular domain Chain: A
Molecule details ›
Chain: A
Length: 59 amino acids
Theoretical weight: 6.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P46531 (Residues: 1721-1771; Coverage: 2%)
Gene names: NOTCH1, TAN1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 40%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Notch signaling pathway: architecture, disease, and therapeutics.
Zhou et al. (2022)
1 more

2 mentions without citation

Substrate-Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype.
Liu et al. (2020)
1 more