PDB 5kzq structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Biochemical function:

G protein-coupled receptor activity

Biological process:

G protein-coupled receptor signaling pathway

Cellular component:

membrane

Sequence domains:

Structure analysis Details

Assembly composition:

monomeric (preferred)

Assembly name:

Metabotropic glutamate receptor 2 (preferred)

PDBe Complex ID:

PDB-CPX-171998 (preferred)

Entry contents:

1 distinct polypeptide molecule

Macromolecule:

Metabotropic glutamate receptor 2 Chain: A

Molecule details ›

Chain: A
Length: 570 amino acids
Theoretical weight: 63.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:

Canonical: Q14416 (Residues: 1-564; Coverage: 64%)

Gene names: GPRC1B, GRM2, MGLUR2
Sequence domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

X-ray source: APS BEAMLINE 31-ID

Spacegroup: P4₁2₁2

Unit cell:

a: 166.297Å b: 166.297Å c: 79.776Å

α: 90° β: 90° γ: 90°

R-values:

R R_work R_free

0.21 0.208 0.245

Expression system: Spodoptera frugiperda

Protein Data Bank in Europe

Metabotropic Glutamate Receptor in complex with antagonist (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Function and Biology Details

Structure analysis Details

Ligands and Environments

Experiments and Validation Details

Quick links

Citations

5 review citations

2 mentions without citation

PDB-REDO

PDBe › 5kzq

Metabotropic Glutamate Receptor in complex with antagonist (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Function and Biology Details

Structure analysis Details

Ligands and Environments

Experiments and Validation Details

Quick links

Citations

5 review citations

2 mentions without citation

PDB-REDO