Function and Biology Details
Reaction catalysed:
L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Aromatic amino acid hydroxylase, C-terminal
- Aromatic amino acid hydroxylase, iron/copper binding site
- Tryptophan 5-hydroxylase, catalytic domain
- Aromatic amino acid monoxygenase, C-terminal domain superfamily
- ACT domain
- ACT-like domain
- Tryptophan 5-monooxygenase
- Aromatic amino acid hydroxylase
2 more domains
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Tryptophan 5-hydroxylase 1 (preferred)
PDBe Complex ID:
PDB-CPX-148158 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryptophan 5-hydroxylase 1
Molecule details ›
Chain: A
Length: 444 amino acids
Theoretical weight: 51.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
Sequence domains: Biopterin-dependent aromatic amino acid hydroxylase
Structure domains: Aromatic amino acid hydroxylase
Length: 444 amino acids
Theoretical weight: 51.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
- Canonical:
P17752 (Residues: 1-444; Coverage: 100%)
Sequence domains: Biopterin-dependent aromatic amino acid hydroxylase
Structure domains: Aromatic amino acid hydroxylase
