Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149970 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase JAK1
Molecule details ›
Chain: A
Length: 550 amino acids
Theoretical weight: 63.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 550 amino acids
Theoretical weight: 63.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P23458 (Residues: 31-577; Coverage: 47%)
Sequence domains:
Interferon lambda receptor 1
Molecule details ›
Chain: B
Length: 48 amino acids
Theoretical weight: 5.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Length: 48 amino acids
Theoretical weight: 5.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q8IU57 (Residues: 260-307; Coverage: 10%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
APS BEAMLINE 22-ID
Spacegroup:
C2
Expression system: Escherichia coli
