› 5l0a

X-ray diffraction
2.3Å resolution

Human muscle fructose-1,6-bisphosphatase E69Q mutant in active R-state in complex with fructose-1,6-bisphosphate

Released:
DOI: 10.2210/pdb5l0a/pdb
PDB entry 5l0a coloured by chain, front view.
PDB entry 5l0a coloured by chain, side view.
PDB entry 5l0a coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Barciszewski J, Wisniewski J, Kolodziejczyk R, Dzugaj A, Jaskolski M, Rakus D

Function and Biology Details

Reaction catalysed: 
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126382 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fructose-1,6-bisphosphatase isozyme 2 Chain: A
Molecule details ›
Chain: A
Length: 338 amino acids
Theoretical weight: 36.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00757 (Residues: 2-339; Coverage: 100%)
Gene name: FBP2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FBP 1 x FBP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.3
Spacegroup: I4122
Unit cell:
a: 72.446Å b: 72.446Å c: 233.954Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.215 0.288
Expression system: Escherichia coli

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