› 5l0n

X-ray diffraction
1.28Å resolution

PKG I's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with RP-cGMP

Released:
DOI: 10.2210/pdb5l0n/pdb
PDB entry 5l0n coloured by chain, front view.
PDB entry 5l0n coloured by chain, side view.
PDB entry 5l0n coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Campbell JC, Sankaran B, Kim CW

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171844 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cGMP-dependent protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 14.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13976 (Residues: 204-336; Coverage: 20%)
Gene names: PRKG1, PRKG1B, PRKGR1A, PRKGR1B
Sequence domains: Cyclic nucleotide-binding domain
Structure domains: Jelly Rolls

Ligands and Environments

4 bound ligands:
Ligand SO4 1 x SO4
Ligand EDO 3 x EDO
Ligand CA 1 x CA
Ligand 6ZA 1 x 6ZA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 39.889Å b: 54.305Å c: 56.45Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.167 0.182
Expression system: Escherichia coli

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