› 5l11

X-ray diffraction
1.85Å resolution

Human Liver Receptor Homologue-1 (LRH-1) Bound to RJW100 and a Fragment of TIF-2

Released:
DOI: 10.2210/pdb5l11/pdb
PDB entry 5l11 coloured by chain, front view.
PDB entry 5l11 coloured by chain, side view.
PDB entry 5l11 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists.
Mays SG, Okafor CD, Whitby RJ, Goswami D, Stec J, Flynn AR, Dugan MC, Jui NT, Griffin PR, Ortlund EA
J Biol Chem 291 25281-25291 (2016)
PMID: 27694446

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126310 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor subfamily 5 group A member 2 Chain: A
Molecule details ›
Chain: A
Length: 245 amino acids
Theoretical weight: 28.33 KDa
Source organism: Homo sapiens
Expression system: Enterobacteria phage L1
UniProt:
  • Canonical: O00482 (Residues: 299-541; Coverage: 45%)
Gene names: B1F, CPF, FTF, NR5A2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chain: C
Molecule details ›
Chain: C
Length: 14 amino acids
Theoretical weight: 1.71 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 740-753; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand RJW 1 x RJW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 46.418Å b: 46.418Å c: 220.259Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.198 0.241
Expression systems:
  • Enterobacteria phage L1
  • Not provided

Quick links

Citations

1 review citation

International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023.
Burris et al. (2023)
4 other articles

13 mentions without citation

Structure, expression profile and phylogenetic inference of chalcone isomerase-like genes from the narrow-leafed lupin (Lupinus angustifolius L.) genome.
Przysiecka et al. (2015)
12 more