› 5l19

X-ray diffraction
2Å resolution

Crystal Structure of a human FasL mutant

Released:
DOI: 10.2210/pdb5l19/pdb
PDB entry 5l19 coloured by chain, front view.
PDB entry 5l19 coloured by chain, side view.
PDB entry 5l19 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3.
Liu W, Ramagopal U, Cheng H, Bonanno JB, Toro R, Bhosle R, Zhan C, Almo SC
Structure 24 2016-2023 (2016)
PMID: 27806260

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155691 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 6, soluble form Chain: A
Molecule details ›
Chain: A
Length: 153 amino acids
Theoretical weight: 17.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpB1_S
UniProt:
  • Canonical: P48023 (Residues: 130-281; Coverage: 54%)
Gene names: APT1LG1, CD95L, FASL, FASLG, TNFSF6
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P321
Unit cell:
a: 52.69Å b: 52.69Å c: 87.385Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.168 0.165 0.216
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpB1_S

Quick links

Citations

7 review citations

Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures.
Felix et al. (2017)
6 more

4 mentions without citation

Bulbus Fritillariae Cirrhosae as a Respiratory Medicine: Is There a Potential Drug in the Treatment of COVID-19?
Quan et al. (2021)
3 more