› 5l6y

X-ray diffraction
1.99Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211094 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-13 Chain: C
Molecule details ›
Chain: C
Length: 112 amino acids
Theoretical weight: 12.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35225 (Residues: 35-146; Coverage: 92%)
Gene names: IL13, NC30
Sequence domains: Interleukin-13
Structure domains: Growth Hormone; Chain: A;
tralokinumab FAb digest VH Chain: H
Molecule details ›
Chain: H
Length: 238 amino acids
Theoretical weight: 25.33 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
tralokiumab FAb digest VL Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 22.68 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand FMT 15 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 50.998Å b: 53.195Å c: 62.05Å
α: 107.91° β: 101.42° γ: 96.94°
R-values:
R R work R free
0.19 0.189 0.211
Expression systems:
  • Escherichia coli
  • Cricetulus griseus

Quick links

Citations

41 review citations

Commonality of the IL-4/IL-13 pathway in atopic diseases.
Gandhi et al. (2017)
40 more

6 mentions without citation

RosettaAntibodyDesign (RAbD): A general framework for computational antibody design.
Adolf-Bryfogle et al. (2018)
5 more