› 5l73

X-ray diffraction
2.24Å resolution

MAM domain of human neuropilin-1

Released:
DOI: 10.2210/pdb5l73/pdb
PDB entry 5l73 coloured by chain, front view.
PDB entry 5l73 coloured by chain, side view.
PDB entry 5l73 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of the Neuropilin-1 MAM Domain: Completing the Neuropilin-1 Ectodomain Picture.
Yelland T, Djordjevic S
Structure 24 2008-2015 (2016)
PMID: 27720589

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127141 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuropilin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 192 amino acids
Theoretical weight: 22.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O14786 (Residues: 628-813; Coverage: 21%)
Gene names: NRP, NRP1, VEGF165R
Sequence domains: MAM domain, meprin/A5/mu
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand CA 4 x CA
Ligand BCN 2 x BCN
Ligand TAM 1 x TAM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 46.172Å b: 59.558Å c: 136.654Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.172 0.228
Expression system: Homo sapiens

Quick links

Citations

8 review citations

Regulation of tumor angiogenesis by microRNAs: State of the art.
Goradel et al. (2019)
7 more

6 mentions without citation

A widespread viral entry mechanism: The C-end Rule motif-neuropilin receptor interaction.
Balistreri et al. (2021)
5 more