Function and Biology Details
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-130889 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ubiquitin carboxyl-terminal hydrolase 12
Molecule details ›
Chain: A
Length: 376 amino acids
Theoretical weight: 43.74 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Ubiquitin carboxyl-terminal hydrolase
Length: 376 amino acids
Theoretical weight: 43.74 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
O75317 (Residues: 1-370; Coverage: 100%)
Sequence domains: Ubiquitin carboxyl-terminal hydrolase
WD repeat-containing protein 48
Molecule details ›
Chain: B
Length: 580 amino acids
Theoretical weight: 65.19 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 580 amino acids
Theoretical weight: 65.19 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q8TAF3 (Residues: 9-580; Coverage: 85%)
Sequence domains:
Ubiquitin
Molecule details ›
Chain: C
Length: 75 amino acids
Theoretical weight: 8.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin family
Length: 75 amino acids
Theoretical weight: 8.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P0CG47 (Residues: 153-227; Coverage: 33%)
Sequence domains: Ubiquitin family
