› 5laq

X-ray diffraction
2.4Å resolution

Function and Biology Details

Reaction catalysed: 
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170460 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3',5'-cyclic-AMP phosphodiesterase 4B Chain: A
Molecule details ›
Chain: A
Length: 421 amino acids
Theoretical weight: 48.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q07343 (Residues: 241-289, 305-659; Coverage: 55%)
Gene names: DPDE4, PDE4B
Sequence domains:
Structure domains: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Ligands and Environments

4 bound ligands:
Ligand ZN 1 x ZN
Ligand MG 1 x MG
Ligand ACT 3 x ACT
Ligand 6M5 1 x 6M5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P3121
Unit cell:
a: 95.737Å b: 95.737Å c: 85.113Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.174 0.171 0.241
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Current Treatments to Control African Trypanosomiasis and One Health Perspective.
Venturelli et al. (2022)
8 other articles

5 mentions without citation

Evaluation of Various Solvent Extracts of Tetrastigma leucostaphylum (Dennst.) Alston Leaves, a Bangladeshi Traditional Medicine Used for the Treatment of Diarrhea.
Rudra et al. (2020)
4 more