› 5lga

X-ray diffraction
2.5Å resolution

Structural analysis and biological activities of BXL0124, a Gemini analog of Vitamin D

Released:
DOI: 10.2210/pdb5lga/pdb
PDB entry 5lga coloured by chain, front view.
PDB entry 5lga coloured by chain, side view.
PDB entry 5lga coloured by chain, top view.
Source organisms:
Primary publication:
Structural analysis and biological activities of BXL0124, a gemini analog of vitamin D.
Belorusova AY, Suh N, Lee HJ, So JY, Maehr H, Rochel N
J Steroid Biochem Mol Biol 173 69-74 (2017)
PMID: 27650654

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172336 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Vitamin D3 receptor A Chain: A
Molecule details ›
Chain: A
Length: 300 amino acids
Theoretical weight: 33.92 KDa
Source organism: Danio rerio
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q9PTN2 (Residues: 156-453; Coverage: 66%)
Gene names: nr1i1a, vdr, vdra
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 686-698; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand 6VH 1 x 6VH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P6522
Unit cell:
a: 65.86Å b: 65.86Å c: 263.83Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.242
Expression systems:
  • Escherichia coli K-12
  • Not provided

Quick links

Citations

1 review citation

Vitamin D and Its Synthetic Analogs.
Maestro et al. (2019)
2 other articles

1 mention without citation

Structural analysis and biological activities of BXL0124, a gemini analog of vitamin D.
Belorusova et al. (2017)