› 5li9

X-ray diffraction
1.79Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154422 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase C iota type Chain: A
Molecule details ›
Chain: A
Length: 350 amino acids
Theoretical weight: 40.48 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P41743 (Residues: 248-596; Coverage: 59%)
Gene names: DXS1179E, PRKCI
Sequence domains:
Structure domains:

Ligands and Environments

6 bound ligands:
Ligand ACP 1 x ACP
Ligand FMT 7 x FMT
Ligand IMD 1 x IMD
Ligand MRD 1 x MRD
Ligand PEG 3 x PEG
Ligand ACT 2 x ACT
1 modified residue:
Ligand TPO 2 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 61.806Å b: 65.143Å c: 87.411Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.231
Expression system: Trichoplusia ni

Quick links

Citations

13 review citations

Protein kinase C: perfectly balanced.
Newton AC. (2018)
12 more