› 5lkn

Solution NMR

NMR solution structure of human FNIII domain 2 of NCAM

Released:
DOI: 10.2210/pdb5lkn/pdb
PDB entry 5lkn coloured by chain, ensemble of 20 models, front view.
PDB entry 5lkn coloured by chain, ensemble of 20 models, side view.
PDB entry 5lkn coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain.
Slapšak U, Salzano G, Amin L, Abskharon RN, Ilc G, Zupančič B, Biljan I, Plavec J, Giachin G, Legname G
J Biol Chem 291 21857-21868 (2016)
PMID: 27535221

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146665 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neural cell adhesion molecule 1 Chain: A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 11.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13591 (Residues: 611-702; Coverage: 11%)
Gene names: NCAM, NCAM1
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

12 review citations

The function of the cellular prion protein in health and disease.
Watts et al. (2018)
11 more

1 mention without citation

The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain.
Slapšak et al. (2016)