› 5llv

X-ray diffraction
1.7Å resolution

Crystal structure of DACM F87M/L110M Transthyretin mutant

Released:
DOI: 10.2210/pdb5llv/pdb
PDB entry 5llv coloured by chain, front view.
PDB entry 5llv coloured by chain, side view.
PDB entry 5llv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
FRET studies of various conformational states adopted by transthyretin.
Ghadami SA, Bemporad F, Sala BM, Tiana G, Ricagno S, Chiti F
Cell Mol Life Sci 74 3577-3598 (2017)
PMID: 28478513

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 128 amino acids
Theoretical weight: 13.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

2 bound ligands:
Ligand CL 3 x CL
Ligand ACT 4 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 64.441Å b: 83.76Å c: 86.53Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.153 0.15 0.223
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers.
Ghadami et al. (2020)
2 more

1 mention without citation

The Structure and Mechanism of Drug Transporters.
Roberts AG. (2021)