› 5loh

X-ray diffraction
3.1Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188523 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase greatwall Chains: A, B
Molecule details ›
Chains: A, B
Length: 341 amino acids
Theoretical weight: 38.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96GX5 (Residues: 1-194, 740-879; Coverage: 38%)
Gene names: GW, GWL, MASTL, THC2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand STU 2 x STU
Ligand CL 1 x CL
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 42.897Å b: 80.283Å c: 179.939Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.206 0.265
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

The Oncogenic Functions of MASTL Kinase.
Marzec et al. (2018)
4 more

4 mentions without citation

Structural, enzymatic and spatiotemporal regulation of PP2A-B55 phosphatase in the control of mitosis.
Lacroix et al. (2022)
3 more