› 5lpl

X-ray diffraction
1.65Å resolution

Crystal structure of the bromodomain of human CREBBP bound to the inhibitor XDM3c

Released:
DOI: 10.2210/pdb5lpl/pdb
PDB entry 5lpl coloured by chain, front view.
PDB entry 5lpl coloured by chain, side view.
PDB entry 5lpl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Hügle M, Lucas X, Ostrovskyi D, Regenass P, Gerhardt S, Einsle O, Hau M, Jung M, Breit B, Günther S, Wohlwend D
Angew Chem Int Ed Engl 56 12476-12480 (2017)
PMID: 28766825

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187751 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CREB-binding protein Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 14.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92793 (Residues: 1081-1197; Coverage: 5%)
Gene names: CBP, CREBBP
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand 71X 1 x 71X
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 88.838Å b: 35.438Å c: 40.503Å
α: 90° β: 93.58° γ: 90°
R-values:
R R work R free
0.165 0.163 0.21
Expression system: Escherichia coli BL21(DE3)

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Citations

4 review citations

Regulation of DNA replication-coupled histone gene expression.
Mei et al. (2017)
3 more