Function and Biology Details
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
OTU domain-containing protein 7B and Ubiquitin (preferred)
PDBe Complex ID:
PDB-CPX-143238 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
OTU domain-containing protein 7B
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 36.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: OTU-like cysteine protease
Length: 318 amino acids
Theoretical weight: 36.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q6GQQ9 (Residues: 129-438; Coverage: 37%)
Sequence domains: OTU-like cysteine protease
Ubiquitin
Molecule details ›
Chain: B
Length: 76 amino acids
Theoretical weight: 8.55 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Ubiquitin family
Length: 76 amino acids
Theoretical weight: 8.55 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P0CG47 (Residues: 153-228; Coverage: 33%)
Sequence domains: Ubiquitin family
Ubiquitin
Molecule details ›
Chain: C
Length: 76 amino acids
Theoretical weight: 8.6 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Ubiquitin family
Length: 76 amino acids
Theoretical weight: 8.6 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P0CG47 (Residues: 153-227; Coverage: 33%)
Sequence domains: Ubiquitin family
