Function and Biology Details
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assemblies composition:
Assembly name:
A20p37 and Ubiquitin (preferred)
PDBe Complex ID:
PDB-CPX-143247 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
A20p50
Molecule details ›
Chains: A, C
Length: 371 amino acids
Theoretical weight: 43.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: OTU-like cysteine protease
Length: 371 amino acids
Theoretical weight: 43.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P21580 (Residues: 1-366; Coverage: 46%)
Sequence domains: OTU-like cysteine protease
Ubiquitin
Molecule details ›
Chains: B, D
Length: 76 amino acids
Theoretical weight: 8.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin family
Length: 76 amino acids
Theoretical weight: 8.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P0CG47 (Residues: 153-228; Coverage: 33%)
Sequence domains: Ubiquitin family
A20p50
Molecule details ›
Chains: E, F
Length: 371 amino acids
Theoretical weight: 43.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: OTU-like cysteine protease
Length: 371 amino acids
Theoretical weight: 43.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P21580 (Residues: 1-366; Coverage: 46%)
Sequence domains: OTU-like cysteine protease
