› 5lwy

X-ray diffraction
2.4Å resolution

Revised crystal structure of the human adiponectin receptor 2 in complex with a C18 free fatty acid

Released:
DOI: 10.2210/pdb5lwy/pdb
PDB entry 5lwy coloured by chain, front view.
PDB entry 5lwy coloured by chain, side view.
PDB entry 5lwy coloured by chain, top view.
Source organisms:
Primary publication:
Structural insights into adiponectin receptors suggest ceramidase activity.
Vasiliauskaité-Brooks I, Sounier R, Rochaix P, Bellot G, Fortier M, Hoh F, De Colibus L, Bechara C, Saied EM, Arenz C, Leyrat C, Granier S
Nature 544 120-123 (2017)
PMID: 28329765

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212540 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Adiponectin receptor protein 2 Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.1 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q86V24 (Residues: 100-386; Coverage: 74%)
Gene names: ADIPOR2, PAQR2
Sequence domains: Haemolysin-III related
V REGION HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 119 amino acids
Theoretical weight: 13.16 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
Structure domains: Immunoglobulins
V REGION LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 107 amino acids
Theoretical weight: 11.65 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
Structure domains: Immunoglobulins

Ligands and Environments

4 bound ligands:
Ligand ZN 1 x ZN
Ligand OLB 8 x OLB
Ligand OLA 1 x OLA
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Unit cell:
a: 74.58Å b: 101.03Å c: 108.63Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.198 0.224
Expression systems:
  • Trichoplusia ni
  • Drosophila melanogaster

Quick links

Citations

51 review citations

Sphingolipids and their metabolism in physiology and disease.
Hannun et al. (2018)
50 more

4 mentions without citation

Structural insights into adiponectin receptors suggest ceramidase activity.
Vasiliauskaité-Brooks et al. (2017)
3 more