› 5lx5

X-ray diffraction
1.88Å resolution

CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782-RP.

Released:
DOI: 10.2210/pdb5lx5/pdb
PDB entry 5lx5 coloured by chain, front view.
PDB entry 5lx5 coloured by chain, side view.
PDB entry 5lx5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bertrand T, Marquette JP

Function and Biology Details

Reaction catalysed: 
Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155082 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nicotinamide phosphoribosyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 493 amino acids
Theoretical weight: 55.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43490 (Residues: 1-491; Coverage: 100%)
Gene names: NAMPT, PBEF, PBEF1
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments

2 bound ligands:
Ligand 7A0 2 x 7A0
Ligand DPO 2 x DPO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 60.71Å b: 106.69Å c: 83.46Å
α: 90° β: 96.76° γ: 90°
R-values:
R R work R free
0.163 0.163 0.196
Expression system: Escherichia coli

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