› 5lxa

X-ray diffraction
3Å resolution

CRYSTAL STRUCTURE OF HUMAN ADIPONECTIN RECEPTOR 2 IN COMPLEX WITH A C18 FREE FATTY ACID AT 3.0 ANGSTROM RESOLUTION

Released:
DOI: 10.2210/pdb5lxa/pdb
PDB entry 5lxa coloured by chain, front view.
PDB entry 5lxa coloured by chain, side view.
PDB entry 5lxa coloured by chain, top view.
Source organisms:
Primary publication:
Structural insights into adiponectin receptors suggest ceramidase activity.
Vasiliauskaité-Brooks I, Sounier R, Rochaix P, Bellot G, Fortier M, Hoh F, De Colibus L, Bechara C, Saied EM, Arenz C, Leyrat C, Granier S
Nature 544 120-123 (2017)
PMID: 28329765

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212542 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Adiponectin receptor protein 2 Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 35.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q86V24 (Residues: 100-386; Coverage: 74%)
Gene names: ADIPOR2, PAQR2
Sequence domains: Haemolysin-III related
Anti-CD30 moab Ki-4 scFv Chain: H
Molecule details ›
Chain: H
Length: 286 amino acids
Theoretical weight: 30.03 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand OLA 1 x OLA
Ligand OLB 1 x OLB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Unit cell:
a: 74.164Å b: 100.858Å c: 110.389Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.199 0.254
Expression systems:
  • Spodoptera frugiperda
  • Drosophila melanogaster

Quick links

Citations

50 review citations

The endocrine function of adipose tissues in health and cardiometabolic disease.
Scheja et al. (2019)
49 more

1 mention without citation

Structural insights into adiponectin receptors suggest ceramidase activity.
Vasiliauskaité-Brooks et al. (2017)