› 5m24

X-ray diffraction
1.69Å resolution

RARg mutant-S371E

Released:
DOI: 10.2210/pdb5m24/pdb
PDB entry 5m24 coloured by chain, front view.
PDB entry 5m24 coloured by chain, side view.
PDB entry 5m24 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Allosteric Regulation in the Ligand Binding Domain of Retinoic Acid Receptorγ.
Chebaro Y, Sirigu S, Amal I, Lutzing R, Stote RH, Rochette-Egly C, Rochel N, Dejaegere A
PLoS One 12 e0171043 (2017)
PMID: 28125680

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146677 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 250 amino acids
Theoretical weight: 28.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P13631 (Residues: 178-423; Coverage: 54%)
Gene names: NR1B3, RARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

3 bound ligands:
Ligand 9CR 1 x 9CR
Ligand LMU 1 x LMU
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P41212
Unit cell:
a: 59.871Å b: 59.871Å c: 157.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.234
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

1 review citation

Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use and Toxicity.
Carazo et al. (2021)
1 other article

1 mention without citation

Allosteric Regulation in the Ligand Binding Domain of Retinoic Acid Receptorγ.
Chebaro et al. (2017)