› 5m2c

X-ray diffraction
1.96Å resolution

Structural tuning of CD81LEL (space group P32 1 2)

Released:
DOI: 10.2210/pdb5m2c/pdb
PDB entry 5m2c coloured by chain, front view.
PDB entry 5m2c coloured by chain, side view.
PDB entry 5m2c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of Structural Tuning of the Hepatitis C Virus Human Cellular Receptor CD81 Large Extracellular Loop.
Cunha ES, Sfriso P, Rojas AL, Roversi P, Hospital A, Orozco M, Abrescia NGA
Structure 25 53-65 (2017)
PMID: 27916518

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157955 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD81 antigen Chains: A, B
Molecule details ›
Chains: A, B
Length: 101 amino acids
Theoretical weight: 11.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P60033 (Residues: 112-201; Coverage: 38%)
Gene names: CD81, TAPA1, TSPAN28
Sequence domains: Tetraspanin family
Structure domains: Tetraspanin

Ligands and Environments

1 bound ligand:
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P3212
Unit cell:
a: 49.879Å b: 49.879Å c: 132.439Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.204 0.234
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Conformational Flexibility in the CD81-Binding Site of the Hepatitis C Virus Glycoprotein E2.
Ströh et al. (2018)
2 more

1 mention without citation

Structural insights into hepatitis C virus receptor binding and entry.
Kumar et al. (2021)