Function and Biology Details
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- RNA polymerase II, heptapeptide repeat, eukaryotic
- PB2, C-terminal
- Influenza RNA-dependent RNA polymerase subunit PB1
- Influenza RNA-dependent RNA polymerase subunit PB2
- RNA-directed RNA polymerase, negative-strand RNA virus
- Influenza RNA-dependent RNA polymerase subunit PA
- Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
Structure analysis Details
Assembly composition:
hetero heptamer (preferred)
PDBe Complex ID:
PDB-CPX-124813 (preferred)
Entry contents:
4 distinct polypeptide molecules
2 distinct RNA molecules
2 distinct RNA molecules
Macromolecules (6 distinct):
Polymerase acidic protein
Molecule details ›
Chain: A
Length: 728 amino acids
Theoretical weight: 84.24 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
Length: 728 amino acids
Theoretical weight: 84.24 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
- Canonical:
H6QM92 (Residues: 1-713; Coverage: 100%)
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
RNA-directed RNA polymerase catalytic subunit
Molecule details ›
Chain: B
Length: 776 amino acids
Theoretical weight: 87.94 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Length: 776 amino acids
Theoretical weight: 87.94 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
- Canonical: H6QM91 (Residues: 1-756; Coverage: 100%)
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Polymerase basic protein 2
Molecule details ›
Chain: C
Length: 797 amino acids
Theoretical weight: 90.17 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 797 amino acids
Theoretical weight: 90.17 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
- Canonical: H6QM90 (Residues: 1-760; Coverage: 100%)
Sequence domains:
- Influenza RNA polymerase PB2 N-terminal region
- Influenza RNA polymerase PB2 second domain
- Influenza RNA polymerase PB2 middle domain
- Influenza RNA polymerase PB2 helical domain
- Influenza RNA polymerase PB2 CAP binding domain
- Influenza RNA polymerase PB2 6th domain
- Influenza RNA polymerase PB2 C-terminal domain
DNA-directed RNA polymerase II subunit RPB1
Molecule details ›
Chains: X, Y
Length: 28 amino acids
Theoretical weight: 3.22 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: RNA polymerase Rpb1 C-terminal repeat
Length: 28 amino acids
Theoretical weight: 3.22 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P24928 (Residues: 1713-1740; Coverage: 1%)
Sequence domains: RNA polymerase Rpb1 C-terminal repeat
