› 5m3t

X-ray diffraction
2.02Å resolution

Structural tuning of CD81LEL (space group P64)

Released:
DOI: 10.2210/pdb5m3t/pdb
PDB entry 5m3t coloured by chain, front view.
PDB entry 5m3t coloured by chain, side view.
PDB entry 5m3t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of Structural Tuning of the Hepatitis C Virus Human Cellular Receptor CD81 Large Extracellular Loop.
Cunha ES, Sfriso P, Rojas AL, Roversi P, Hospital A, Orozco M, Abrescia NGA
Structure 25 53-65 (2017)
PMID: 27916518

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157955 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD81 antigen Chains: A, B
Molecule details ›
Chains: A, B
Length: 101 amino acids
Theoretical weight: 11.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P60033 (Residues: 112-201; Coverage: 38%)
Gene names: CD81, TAPA1, TSPAN28
Sequence domains: Tetraspanin family
Structure domains: Tetraspanin

Ligands and Environments

2 bound ligands:
Ligand CL 3 x CL
Ligand EDO 6 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P64
Unit cell:
a: 101.3Å b: 101.3Å c: 35.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.174 0.172 0.208
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Conformational Flexibility in the CD81-Binding Site of the Hepatitis C Virus Glycoprotein E2.
Ströh et al. (2018)
2 more

1 mention without citation

Green Synthesis, Experimental and Theoretical Studies to Discover Novel Binders of Exosomal Tetraspanin CD81 Protein.
Anand et al. (2020)