› 5m3x

X-ray diffraction
2.63Å resolution

Crystal structure of human angiotensin I-deleted angiotensinogen

Released:
DOI: 10.2210/pdb5m3x/pdb
PDB entry 5m3x coloured by chain, front view.
PDB entry 5m3x coloured by chain, side view.
PDB entry 5m3x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the specificity of renin-mediated angiotensinogen cleavage.
Yan Y, Zhou A, Carrell RW, Read RJ
J Biol Chem 294 2353-2364 (2019)
PMID: 30563843

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133805 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiotensinogen Chains: A, B
Molecule details ›
Chains: A, B
Length: 448 amino acids
Theoretical weight: 49.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01019 (Residues: 35-476; Coverage: 98%)
Gene names: AGT, SERPINA8
Sequence domains: Serpin (serine protease inhibitor)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P2
Unit cell:
a: 86.3Å b: 41.04Å c: 129.95Å
α: 90° β: 107.82° γ: 90°
R-values:
R R work R free
0.244 0.242 0.282
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Angiotensinogen and the Modulation of Blood Pressure.
Shu et al. (2021)
3 more

1 mention without citation

Structural basis for the specificity of renin-mediated angiotensinogen cleavage.
Yan et al. (2019)